[et_pb_section fb_built=”1″ theme_builder_area=”post_content” _builder_version=”4.26.0″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″][et_pb_row _builder_version=”4.26.0″ _module_preset=”default” column_structure=”1_2,1_2″ theme_builder_area=”post_content” hover_enabled=”0″ sticky_enabled=”0″][et_pb_column _builder_version=”4.26.0″ _module_preset=”default” type=”1_2″ theme_builder_area=”post_content”][et_pb_image src=”http:\/\/172.17.1.35\/wp-content\/uploads\/2025\/02\/Maglangitmolecules-logo.webp” _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content” title_text=”Maglangitmolecules-logo” box_shadow_style=”preset4″ box_shadow_vertical=”13px” box_shadow_blur=”9px” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column _builder_version=”4.26.0″ _module_preset=”default” type=”1_2″ theme_builder_area=”post_content”][et_pb_text _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content” content_last_edited=”on|desktop” hover_enabled=”0″ sticky_enabled=”0″ content_tablet=”<\/p>\n
Authors<\/strong><\/p>\n Fleurdeliz Maglangit<\/strong><\/span> <\/p>\n Qing Fang ” content_phone=”<\/p>\n Authors<\/strong><\/p>\n Fleurdeliz Maglangit<\/strong><\/span> <\/p>\n Qing Fang “]<\/p>\n Authors<\/strong><\/p>\n Fleurdeliz Maglangit<\/strong><\/span> <\/p>\n Qing Fang [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content”][et_pb_column _builder_version=”4.26.0″ _module_preset=”default” type=”4_4″ theme_builder_area=”post_content”][et_pb_text _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content”]<\/p>\n Abstract<\/strong><\/p>\n The isolation and characterization of bioactive metabolites from Streptomyces species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we characterize a new siderophore called legonoxamine I, together with a known compound, streptimidone, from the talented soil bacterium Streptomyces sp. MA37, using chromatographic techniques and spectroscopic analysis. Legonoxamine I is a new holo-siderophore, which is likely to be a derailed product from the biosynthetic pathway of legonoxamine A. We also demonstrate that legonoxamine A possesses potent anticancer activity (IC50 = 2.2 \u00b5M), exhibiting a remarkable ~30-fold increase in potency against MCF-7 ATCC HTB-22 breast cancer cells compared to desferrioxamine B, a structural analogue of legonoxamine A (IC50 = 61.1 \u00b5M). Comparing the structural difference between legonoxamine A and desferrioxamine B, it is deduced that the phenylacetyl moiety in legonoxamine A may have contributed significantly to its enhanced potency. Our findings contribute to the growing library of Streptomyces-derived metabolites and underscore the genus\u2019 potential as a promising source of lead compounds.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.26.0″ _module_preset=”default” column_structure=”1_2,1_2″ theme_builder_area=”post_content” box_shadow_style=”preset1″ hover_enabled=”0″ sticky_enabled=”0″][et_pb_column _builder_version=”4.26.0″ _module_preset=”default” type=”1_2″ theme_builder_area=”post_content”][et_pb_text _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Keywords<\/strong><\/p>\n legonoxamine; hydroxamate; hydroxylamine; iron chelators<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column _builder_version=”4.26.0″ _module_preset=”default” type=”1_2″ theme_builder_area=”post_content”][et_pb_text _builder_version=”4.26.0″ _module_preset=”default” theme_builder_area=”post_content” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n Link to the article<\/strong><\/p>\n https:\/\/doi.org\/10.3390\/molecules30020306<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Authors Fleurdeliz MaglangitDepartment of Biology and Environmental Science, College of Science, University of the Philippines Cebu Qing FangJioji N. TabudravuKwaku KyeremehMarcel JasparsHai Deng Abstract The isolation and characterization of bioactive metabolites from Streptomyces species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we […]<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[34],"project_tag":[],"class_list":["post-1728","project","type-project","status-publish","hentry","project_category-recent-publications"],"_links":{"self":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":1,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1728\/revisions"}],"predecessor-version":[{"id":1879,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1728\/revisions\/1879"}],"wp:attachment":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/media?parent=1728"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project_category?post=1728"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project_tag?post=1728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu<\/strong><\/p>\n
Jioji N. Tabudravu
Kwaku Kyeremeh
Marcel Jaspars
Hai Deng<\/p>\n
Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu<\/strong><\/p>\n
Jioji N. Tabudravu
Kwaku Kyeremeh
Marcel Jaspars
Hai Deng<\/p>\n
Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu<\/strong><\/p>\n
Jioji N. Tabudravu
Kwaku Kyeremeh
Marcel Jaspars
Hai Deng<\/p>\n