{"id":1441,"date":"2024-04-15T02:26:41","date_gmt":"2024-04-15T02:26:41","guid":{"rendered":"https:\/\/cvsc.upcebu.edu.ph\/?p=1441"},"modified":"2025-11-13T10:19:27","modified_gmt":"2025-11-13T10:19:27","slug":"accraspiroketides-a-b-phenylnaphthacenoid-derived-polyketides-with-unprecedented-6-66-6-5-5-spiro-architecture","status":"publish","type":"project","link":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/project\/accraspiroketides-a-b-phenylnaphthacenoid-derived-polyketides-with-unprecedented-6-66-6-5-5-spiro-architecture\/","title":{"rendered":"Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture"},"content":{"rendered":"\n[et_pb_section fb_built=&#8221;1&#8243; theme_builder_area=&#8221;post_content&#8221; _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][et_pb_row _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; column_structure=&#8221;1_3,1_3,1_3&#8243; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;1_3&#8243; theme_builder_area=&#8221;post_content&#8221;][et_pb_image src=&#8221;http:\/\/172.17.1.35\/wp-content\/uploads\/2024\/10\/Accraspiroketides-Maglangit.jpg&#8221; _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; title_text=&#8221;Accraspiroketides-Maglangit&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;38px&#8221; box_shadow_vertical=&#8221;-35px&#8221; box_shadow_spread=&#8221;-13px&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;1_3&#8243; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<h2><strong>Authors<\/strong><\/h2>\n<h3><span style=\"color: #3366ff;\"><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" tabindex=\"0\">Fleurdeliz Maglangit\u00a0<\/span><\/span><\/h3>\n<p><span><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" tabindex=\"0\">Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu<\/span><\/span><\/p>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Shan Wang<\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Arvin Moser<\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Kwaku Kyeremeh<\/span><\/h3>\n<p>&nbsp;<\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;1_3&#8243; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<ul class=\"loa\"><\/ul>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Laurent Trembleau<\/span><\/h3>\n<div class=\"loa-info hlFld-Affiliation\">\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\"><\/span><\/h3>\n<h3><span style=\"color: #3366ff;\"><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" tabindex=\"0\">Yongjun <\/span><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" tabindex=\"0\">Zhou<\/span><\/span><\/h3>\n<div class=\"loa-info hlFld-Affiliation\">\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\"><\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">David James Clark<\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\"><\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Jioji Tabudravu<\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\"><\/span><\/h3>\n<h3><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" style=\"color: #3366ff;\" tabindex=\"0\">Hai Deng<\/span><\/h3>\n<p><span><span class=\"hlFld-ContribAuthor\" data-id=\"article_author_info\" property=\"author\" tabindex=\"0\"><\/span><\/span><\/p>\n<div class=\"loa-info hlFld-Affiliation\"><\/div>\n<\/div>\n<\/div>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;4_4&#8243; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<h2><strong>Abstract<\/strong><\/h2>\n<p>Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 + 5] spiro chemical architectures, were isolated from\u00a0<i>Streptomyces<\/i>\u00a0sp. MA37 \u0394<i>accJ<\/i>\u00a0mutant strain. Compounds\u00a01-2\u00a0exhibit excellent activity against Gram-positive bacteria (MIC = 1.5\u20136.3 \u03bcg\/mL). Notably,\u00a01\u00a0and\u00a02\u00a0have superior activity against clinically isolated\u00a0<i>Enterococcus faecium<\/i>\u00a0K60\u201339 (MIC = 4.0 \u03bcg\/mL and 4.7 \u03bcg\/mL, respectively) than ampicillin (MIC = 25 \u03bcg\/mL).<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; column_structure=&#8221;1_2,1_2&#8243; theme_builder_area=&#8221;post_content&#8221; box_shadow_style=&#8221;preset1&#8243; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;1_2&#8243; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<h2><strong>Link to the article:<\/strong><\/h2>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.3c01012\">https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.3c01012<\/a>\u00a0<\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column _builder_version=&#8221;4.26.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;1_2&#8243; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>Authors Fleurdeliz Maglangit\u00a0 Department of Biology and Environmental Science, College of Science, University of the Philippines Cebu Shan Wang Arvin Moser Kwaku Kyeremeh &nbsp; Laurent Trembleau Yongjun Zhou David James Clark Jioji Tabudravu Hai Deng Abstract Two novel polyketides, accraspiroketides A (1) and B (2), which feature unprecedented [6 + 6+6 + 6] + [5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[34],"project_tag":[],"class_list":["post-1441","project","type-project","status-publish","hentry","project_category-recent-publications"],"_links":{"self":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1441\/revisions"}],"predecessor-version":[{"id":2920,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project\/1441\/revisions\/2920"}],"wp:attachment":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/media?parent=1441"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project_category?post=1441"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/project_tag?post=1441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}