{"id":669,"date":"2020-07-07T09:00:27","date_gmt":"2020-07-07T09:00:27","guid":{"rendered":"http:\/\/cvsc.upcebu.edu.ph\/?p=669"},"modified":"2020-07-07T09:00:27","modified_gmt":"2020-07-07T09:00:27","slug":"novel-south-african-rare-actinomycete-kribbell-speibonae-strain-sk5-a-prolific-producer-of-hydroxamate-siderophores-including-dehydroxylated-congeners","status":"publish","type":"post","link":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/2020\/07\/07\/novel-south-african-rare-actinomycete-kribbell-speibonae-strain-sk5-a-prolific-producer-of-hydroxamate-siderophores-including-dehydroxylated-congeners\/","title":{"rendered":"Novel South African Rare Actinomycete <\/em>Kribbell speibonae<\/em> Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including Dehydroxylated Congeners"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"111\" src=\"http:\/\/172.17.1.35\/wp-content\/uploads\/2020\/09\/image-2-1024x111.png\" alt=\"\" class=\"wp-image-672\" srcset=\"https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-2-1024x111.png 1024w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-2-300x33.png 300w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-2-768x83.png 768w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-2.png 1032w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"485\" src=\"http:\/\/172.17.1.35\/wp-content\/uploads\/2020\/09\/image-3-1024x485.png\" alt=\"\" class=\"wp-image-673\" srcset=\"https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-3-1024x485.png 1024w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-3-300x142.png 300w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-3-768x364.png 768w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-3.png 1216w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"430\" height=\"130\" src=\"http:\/\/172.17.1.35\/wp-content\/uploads\/2020\/09\/image-1.png\" alt=\"\" class=\"wp-image-670\" srcset=\"https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-1.png 430w, https:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2020\/09\/image-1-300x91.png 300w\" sizes=\"(max-width: 430px) 100vw, 430px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D1 2, have been isolated, together with four known hydroxamates, desferrioxamine D1 3, desferrioxamine B 4, desoxy-nocardamine 5 and nocardamine 6, and a diketopiperazine (DKP) 7. The structures of 1\u20137 were characterized by the analysis of HRESIMS and 1D and 2D NMR data, as well as by comparison with the relevant literature. Three new dehydroxy desferrioxamine derivatives 8\u201310 were tentatively identified in the molecular network of K. speibonae strain SK5 extracts, and<br \/>structures were proposed based on their MS\/MS fragmentation patterns. A plausible spb biosynthetic pathway was proposed. To the best of our knowledge, this is the first report of the isolation of desferrioxamines from the actinobacterial genus Kribbella. <\/p>\n\n\n\n<p>Keywords: Kribbella; speibonoxamine; siderophore; hydroxamate; molecular networking; mass<br \/>spectrometry<\/p>\n\n\n\n<p>Link to the Article<\/p>\n\n\n\n<p>doi:&nbsp;<a href=\"https:\/\/dx.doi.org\/10.3390%2Fmolecules25132979\">10.3390\/molecules25132979<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated desferrioxamines, speibonoxamine 1 and desoxy-desferrioxamine D1 2, have been isolated, together with four known hydroxamates, desferrioxamine D1 3, desferrioxamine B 4, desoxy-nocardamine 5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[7],"tags":[],"class_list":["post-669","post","type-post","status-publish","format-standard","hentry","category-recent-publications"],"_links":{"self":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/posts\/669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/comments?post=669"}],"version-history":[{"count":0,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/posts\/669\/revisions"}],"wp:attachment":[{"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/media?parent=669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/categories?post=669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/wp-json\/wp\/v2\/tags?post=669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}