{"id":3496,"date":"2025-02-05T07:09:17","date_gmt":"2025-02-05T07:09:17","guid":{"rendered":"https:\/\/cvsc.upcebu.edu.ph\/?p=3496"},"modified":"2026-08-19T07:09:49","modified_gmt":"2026-08-19T07:09:49","slug":"isolation-and-bioactivity-of-natural-products-from-streptomyces-sp-ma37","status":"publish","type":"post","link":"https:\/\/cvsc.upcebu.edu.ph\/index.php\/2025\/02\/05\/isolation-and-bioactivity-of-natural-products-from-streptomyces-sp-ma37\/","title":{"rendered":"Isolation and Bioactivity of Natural Products from Streptomyces sp. MA37"},"content":{"rendered":"

[et_pb_section fb_built=”1″ theme_builder_area=”post_content” _builder_version=”4.27.7″ _module_preset=”default”][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”40px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_image src=”http:\/\/cvsc.upcebu.edu.ph\/wp-content\/uploads\/2026\/08\/Maglangitmolecules-logo.webp” title_text=”Maglangitmolecules-logo” _builder_version=”4.27.7″ _module_preset=”default” hover_enabled=”0″ box_shadow_style=”preset2″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.7″ _module_preset=”default” text_font_size=”15px” text_line_height=”1.2em” custom_padding=”0px|||||” hover_enabled=”0″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″]<\/p>\n

Lead Researcher(s): Fleurdeliz Maglangit<\/strong>, Qing Fang, Jioji N. Tabudravu,\u00a0 Kwaku Kyeremeh, Marcel Jaspars & Hai Deng<\/p>\n

Status:<\/strong> Published<\/p>\n

Abstract: <\/strong><\/span>The isolation and characterization of bioactive metabolites from\u00a0<\/span>Streptomyces<\/span>\u00a0<\/span>species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we characterize a new siderophore called legonoxamine I, together with a known compound, streptimidone, from the talented soil bacterium\u00a0<\/span>Streptomyces<\/span>\u00a0<\/span>sp. MA37, using chromatographic techniques and spectroscopic analysis. Legonoxamine I is a new holo-siderophore, which is likely to be a derailed product from the biosynthetic pathway of legonoxamine A. We also demonstrate that legonoxamine A possesses potent anticancer activity (IC50<\/sub>\u00a0<\/span>= 2.2 \u00b5M), exhibiting a remarkable ~30-fold increase in potency against MCF-7 ATCC HTB-22 breast cancer cells compared to desferrioxamine B, a structural analogue of legonoxamine A (IC50<\/sub>\u00a0<\/span>= 61.1 \u00b5M). Comparing the structural difference between legonoxamine A and desferrioxamine B, it is deduced that the phenylacetyl moiety in legonoxamine A may have contributed significantly to its enhanced potency. Our findings contribute to the growing library of\u00a0<\/span>Streptomyces<\/span>-derived metabolites and underscore the genus\u2019 potential as a promising source of lead compounds.<\/p>\n

Keywords:<\/b><\/p>\n